2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W011978R
    N-Acetyl-L-tryptophan (Standard) 1218-34-4
    N-Acetyl-L-tryptophan (Standard) is the analytical standard of N-Acetyl-L-tryptophan. This product is intended for research and analytical applications. N-Acetyl-L-tryptophan is an endogenous metabolite.
    N-Acetyl-L-tryptophan (Standard)
  • HY-W012479R
    H-D-Trp-OH (Standard) 153-94-6
    H-D-Trp-OH (Standard) is the analytical standard of H-D-Trp-OH. This product is intended for research and analytical applications. H-D-Trp-OH is a D-stereoisomer of tryptophan and occasionally found in naturally produced peptides such as the marine venom peptide.
    H-D-Trp-OH (Standard)
  • HY-W012572R
    D-Histidine (Standard) 351-50-8
    D-Histidine (Standard) is the analytical standard of D-Histidine (HY-W012572). This product is intended for research and analytical applications. D-Histidine is an anti-biofilm agent that targets bacterial quorum sensing systems (such as RhlI/RhlR pathway) and has antibacterial activity. D-Histidine works by non-covalently binding to bacterial regulatory factors or copper ion complexes, selectively inhibiting bacterial biofilm formation and motility. D-Histidine downregulates quorum sensing-related gene expression, reduces the synthesis of virulence factors (such as alginate and proteases), and interferes with bacterial membrane stability, inhibiting biofilm formation, promoting the disintegration of mature biofilms, and enhancing antibiotic sensitivity. D-Histidine is also an efficient catalyst for the salt-induced peptide formation (SIPF) reaction, which promotes the condensation of amino acids to form dipeptides (such as dialanine and dilysine) by forming a complex with copper ions (Cu2+).
    D-Histidine (Standard)
  • HY-W012946R
    2-Furoic acid (Standard) 88-14-2
    2-Furoic acid (Standard) is the analytical standard of 2-Furoic acid. This product is intended for research and analytical applications. 2-Furoic acid (Furan-2-carboxylic acid) is an organic compound produced through furfural oxidation. 2-Furoic acid exhibits hypolipidemic effet, lowers both serum cholesterol and serum triglyceride levels in rats.
    2-Furoic acid (Standard)
  • HY-W012974S
    3-Amino-2-methylpropanoic acid-d3 1219803-65-2
    3-Amino-2-methylpropanoic acid-d3 is the deuterium labeled 3-Amino-2-methylpropanoic acid[1]. 3-Amino-2-methylpropanoic acid could induce browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors[2].
    3-Amino-2-methylpropanoic acid-d3
  • HY-W012982R
    3-Amino-2-oxazolidinone (Standard) 80-65-9
    3-Amino-2-oxazolidinone (Standard) is the analytical standard of 3-Amino-2-oxazolidinone. This product is intended for research and analytical applications. 3-Amino-2-oxazolidinone (AOZ) is the metabolite of Furazolidone (HY-B1336). 3-Amino-2-oxazolidinone is always be detected as a indicator of furazolidone residues in vivo.
    3-Amino-2-oxazolidinone (Standard)
  • HY-W013014S
    3-Methyl-2-cyclopenten-1-one-d3 208519-89-5
    3-Methyl-2-cyclopenten-1-one-d3 is deuterated labeled Ethyl cinnamate (HY-Y0121). Ethyl cinnamate is a fragrance ingredient used in many fragrance compounds. Ethyl cinnamate is a food flavor and additive for cosmetic products. Ethyl cinnamate is also an excellent clearing reagent for mammalian tissues.
    3-Methyl-2-cyclopenten-1-one-d3
  • HY-W013049S
    Docosanoic acid-d4 1208430-53-8
    Docosanoic acid-d4 (Behenic acid-4) is deuterium labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a Kd of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans.
    Docosanoic acid-d4
  • HY-W013215S
    Adrenic acid-d8
    Adrenic acid-d8 (cis-7,10,13,16-Docosatetraenoic acid-d8) is deuterium-labeled Adrenic acid (HY-W013215).
    Adrenic acid-d8
  • HY-W013579R
    (S)-(+)-Carvone (Standard) 2244-16-8
    (S)-(+)-Carvone (Standard) is the analytical standard of (S)-(+)-Carvone. This product is intended for research and analytical applications. (S)-(+)-Carvone is an orally active natural product. (S)-(+)-Carvone increases the activity of antioxidant enzymes (SOD, CAT) and ROS, reduces the levels of oxidative stress markers (MDA, AChE), reduces the secretion of proinflammatory cytokines (IL-1β, IL-4, IL-6, IL-10), and downregulates NLRP3. (S)-(+)-Carvone increases the activities of caspase-8, -9 and -3. (S)-(+)-Carvone induces apoptotic death. (S)-(+)-Carvone has antimanic-like effect, liver protection and anticancer activity against skin cancer. (S)-(+)-Carvone improves memory and arthritis.
    (S)-(+)-Carvone (Standard)
  • HY-W013636C
    2-Ketoglutaric acid potassium 997-43-3 ≥98.0%
    2-Ketoglutaric acid potassium (Alpha-Ketoglutaric acid potassium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid potassium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid potassium is a reversible inhibitor of tyrosinase with an IC50 value of 15 mM.
    2-Ketoglutaric acid potassium
  • HY-W013816R
    Dipentyl phthalate (Standard) 131-18-0
    Dipentyl phthalate (Standard) is the analytical standard of Dipentyl phthalate. This product is intended for research and analytical applications. Dipentyl phthalate is an endocrine-disrupting phthalate plasticizer. Dipentyl phthalate increases AMPK phosphorylation and decreases AKT1 phosphorylation and SIRT1 levels. Dipentyl phthalate reduces adrenocorticotropic hormone levels. Dipentyl phthalate is a testicular toxicant.
    Dipentyl phthalate (Standard)
  • HY-W014102R
    L-Alanyl-L-glutamine (Standard) 39537-23-0
    L-Alanyl-L-glutamine (Standard) is the analytical standard of L-Alanyl-L-glutamine. This product is intended for research and analytical applications. L-Alanyl-L-glutamine, a glutamine dipeptide, is benefit for the antioxidant system, attenuating inflammation, and may modulate the heat shock protein (HSP) response in catabolic situations.
    L-Alanyl-L-glutamine (Standard)
  • HY-W014839S
    Cyclamic acid-d11 sodium
    Cyclamic acid-d11 (Sodium cyclamate-d11) sodiumis deuterium labeled Cyclamic acid (sodium). Cyclamic acid sodium (Sodium cyclamate) is a commonly used sweetener. Cyclamic acid sodium is toxic to osteoblasts and can inhibit cell proliferation, induce apoptosis and reduce cell mineralization. Cyclamic acid sodium causes focal necrosis of bladder organs in rats in vitro, which can promote bladder cancer, but some studies have shown that low doses of Cyclamic acid sodium have no carcinogenic effect. In addition, Cyclamic acid sodium has no effect on insulin and glucagon secretion induced by arginine.
    Cyclamic acid-d11 sodium
  • HY-W014901R
    4,4'-Dihydroxydiphenylmethane (Standard) 620-92-8
    4,4'-Dihydroxydiphenylmethane (Standard) is the analytical standard of 4,4'-Dihydroxydiphenylmethane. This product is intended for research and analytical applications. 4,4'-Dihydroxydiphenylmethane is a phenolic derivative with antioxidant activities.
    4,4'-Dihydroxydiphenylmethane (Standard)
  • HY-W015300R
    Suberic acid (Standard) 505-48-6
    Suberic acid (Standard) is the analytical standard of Suberic acid. This product is intended for research and analytical applications. Suberic acid is an orally active crystalline dibasic acid. Suberic acid activates the Akt signaling pathway and regulates the expression of molecules related to the TGF-β and MAPK signaling pathways. Suberic acid inhibits skin dryness.
    Suberic acid (Standard)
  • HY-W015301R
    Dimethyl adipate (Standard) 627-93-0
    Dimethyl adipate (Standard) is the analytical standard of Dimethyl adipate. This product is intended for research and analytical applications. Dimethyl adipate (Hexanedioic acid dimethyl ester) is an ester product.
    Dimethyl adipate (Standard)
  • HY-W015309R
    Decanoic acid (Standard) 334-48-5
    Decanoic acid (Standard) is the analytical standard of Decanoic acid. This product is intended for research and analytical applications. Decanoic acid is a key component of the medium-chain triglyceride (MCT) found in coconut oil. Decanoic acid is a brain-penetrant and non-competitive inhibitor of AMPA receptor showing antiseizure activity in rats. Decanoic acid reduces tyrosinase activity and inhibits melanosome maturation. Decanoic acid suppresses the phosphorylation of c-Met and induced apoptosis in hepatocellular carcinoma (HCC) cells by inhibiting the expression of various oncogenic proteins, which is promising for research in the field of mTORC1 signaling, HCC and epilepsy.
    Decanoic acid (Standard)
  • HY-W015780R
    1,4-Dimethoxybenzene (Standard) 150-78-7
    1,4-Dimethoxybenzene (Standard) is the analytical standard of 1,4-Dimethoxybenzene. This product is intended for research and analytical applications. 1,4-Dimethoxybenzene is an endogenous metabolite.
    1,4-Dimethoxybenzene (Standard)
  • HY-W015786R
    4-Ethoxyphenol (Standard) 622-62-8
    L-Amoxicillin (Standard) is the analytical standard of L-Amoxicillin. This product is intended for research and analytical applications. L-Amoxicillin is an antibiotic with activity against a wide range of bacterial infections. L-Amoxicillin is commonly used in antibacterial combinations when used in combination with the β-lactamase inhibitor potassium clavulanic acid. The related substances analysis method for L-Amoxicillin has been developed and validated according to the International Conference on Harmonization (ICH) guidelines, ensuring its effectiveness and accuracy in mixtures. L-Amoxicillin and some of its impurities have been further analyzed in stress testing and stability studies, providing support for optimizing its application.
    4-Ethoxyphenol (Standard)
Cat. No. Product Name / Synonyms Application Reactivity